Nanoparticles Analysis by Atomic Force Microscopy using 3D Visualization Tools.

Interactive 3D visualization tools for nanoparticles amalgamation analysis. 

ScienceGL Inc. has developed 3D AFM data visualization engine that provides researcher the set of interactive 3D measurement tools. These tools helps scientist to measure various important characteristics of the sample in real time. The 3D visualization software is also fast enough to work with live video AFM microscopes. For detailed comparison of the data obtained with AFM for different data acquisition modes we also offer Multiple 3D surface analysis software.

The AFM measured height data is visualized with single surface  3D AFM/SPM software .
The height of the features is exaggerated for better perception of the fine structures.

Fig.1. 3D AFM height image of nanoparticles sample. Raw atomic force microscope data is visualized as 3D surface.
AFM data courtesy   Dr. Kannan Raghuraman,   University of Missouri-Columbia.


Fig.2. 3D AFM height image of nanoparticles. Same data as in Fig.1. but FFT filtered to remove systematic noise.

Fig.3. 3D AFM surface visualized together with volume measuring tool. The tool is adjusted with mouse to features of interest that is nanoparticle group.

Fig.4. AFM height image of nanoparticles sample. 3D surface zoomed to amalgamated nanoparticle pairs. 3D measurement tools read back distance between particles and 1D intersection profile (cut plot).

References. Recent Publications by Dr. Dr. Kannan Raghuraman:

Characterization of Supramolecular (H 2 O) 18 Water Morphology and Water-Methanol (H 2 O) 15 (CH 3 OH) 3 Clusters in a Novel Phosphorus Functionalized Trimeric Amino Acid Host, K. Raghuraman , Kavita K. Katti, Leonard J. Barbour, Nagavarakishore Pillarsetty, Charles L. Barnes, and Kattesh V. Katti, J. Am. Chem. Soc. 2003, 125 , 6955-6961.

Radiochemical Investigations of Gastrin-releasing Peptide Receptor-specific [ 99m Tc(X)(CO) 3 -Dpr-Ser-Ser-Ser-Gln-Trp-Ala-Val-Gly-His-Leu-Met-(NH 2 )] in PC-3, Tumor-bearing, Rodent Models: Syntheses, Radiolabeling, and in Vitro/in Vivo Studies where Dpr = 2,3-Diaminopropionic acid and X = H 2 O or P(CH 2 OH) 3 . Smith, C. Jeffrey; Sieckman, Gary L.; Owen, Nellie K.; Hayes, Donald L.; Mazuru, Dana G.; Kannan, Raghuraman ; Volkert, Wynn A.; Hoffman, Timothy J. Cancer Research 2003, 63 , 4082-4088.

Syntheses, in vitro and in vivo characterization of a 99m Tc(I)-tricarbonyl-benzylamino-dihydroxymethayl phosphine (NP 2 ) chelate, K. K. Kothari, K. Raghuraman , N. K. Pillarsetty, T. J. Hoffman, N. K. Owen, K. V. Katti, W. A. Volkert, Applied Radiation and Isotopes 2003, 58 , 543-549.

Exceptional Kinetic Propensity of Hydroxymethyl Phosphanes Toward Rh(III) Stabilization in Water, K. Raghuraman , N. Pillarsetty, W. A. Volkert, C. Barnes, S. Jurisson and K. V. Katti, J. Am. Chem. Soc. 2002, 124 , 7276-7277.

First Examples of Azaphosphanes as Efficient Electron Donors in the Chemical Architecture of Thermally Stable New Nonlinear Optical Materials, K. V. Katti, K. Raghuraman , N. Pillarsetty, S. R. Karra, R. J. Gulotty, M. A. Chartier, and C. A. Langhoff, Chemistry of Materials 2002, 14 , 2436-2438

Novel Tridentate Water-Soluble Phosphane Based Ligands for Stabilizing Tc(I)/Re(I) Carbonyls for Radiopharmaceutical Applications, K.V. Katti, K. Raghuraman , N. Pillarsetty, W.A. Volkert, S.S. Jurisson and T.J. Hoffman Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine . M. Nicolini, U. Mazzi Eds., SGE Editoriali, Padova , Italy . 2002, 6 , 69.

Novel Green Chemistry in the Phosphonate Assisted Catalytic Hydrogenation of Olefins, K. Raghuraman , N. Pillarsetty, K. R. Prabhu, K. V. Katti, Phosphorus Sulfur and Silicon, 2002, 177 , 1951.

Half-sandwich Cyclopentadienyl Ruthenium Complexes of Achiral and Chiral Diphosphazanes, K. Raghuraman , S. S. Krishnamurthy and M. Nethaji, J. Chem. Soc., Dalton . Trans., 2002, 22 , 4289-4295.

New Phosphorus Chemistry Leads to Unnatural Aminoacid Trimers, K. V. Katti, K. Raghuraman , K. K. Katti, N. Pillarsetty, and C. L. Barnes, Phosphorus Sulfur and Silicon, 2002, 127 , 1587-1589

Synthesis and Characterization of Ru(0), Rh(I), Pd(II) and Pt(II) Complexes Derived from Diphosphazane Monosulfide Ligands: X-ray Crystal Structures of [Ru 3 (m 3-S)(m sb -CO)(CO) 7 {h 2 -(Ph 2 PN(( S )-*CHMePh)PPh 2 )}] and [Rh(CO)Cl {h 2-(Ph ­2 ­PN((S)-*CHMePh)P(S)Ph­2­)}], K. Raghuraman, S. S. Krishnamurthy and M. Nethaji, J.Organometallic Chem., 2003, 669, 79-86.

Organometallic chemistry of Diphosphazane ligands: Synthesis and structural characterization: K. Raghuraman , Swadhin K Mandal, T S Venkatakrishnan, Setharampattu S Krishnamurthy and Munirathinam Nethaji". Proc. Ind. Acad of Sci. (Chem Sci.,) 2002, 114 , 233-246.

Radiochemical Investigations of [99m Tc(H 2 O)(CO) 3 -Dpr-(X)-Bombesin(7-14)NH 2], a New Family of GRP-receptor Targeting Radiopharmaceuticals. Smith, C.J.; Sieckman, G.L.; Owen, N.K.; Hayes, D.L.; Mazuru, D.L.; Kannan, R .; Volkert, W.A.; and Hoffman, T.J. Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine . M. Nicolini, U. Mazzi Eds., SGE Editoriali, Padova, Italy . 2002, 6, 339.

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